{"title":"Cognitive","description":"\u003cp\u003ePeptides examined in neurotrophic, BDNF and GABAergic signalling research.\u003c\/p\u003e","products":[{"product_id":"semax","title":"Semax","description":"\u003cp\u003eSynthetic ACTH(4-10) analogue developed for neurological research.\u003c\/p\u003e\u003ch3\u003eOverview\u003c\/h3\u003e\u003cp\u003eSemax is a synthetic heptapeptide analogue of ACTH(4-10), developed at a Moscow research institute in the 1980s for stroke and cognitive impairment research. The hormonal activity of the parent fragment is engineered out and a Pro-Gly-Pro tail added to resist degradation.\u003c\/p\u003e\u003ch3\u003eResearch applications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eBDNF upregulation\u003c\/li\u003e\n\u003cli\u003eMemory consolidation in research models\u003c\/li\u003e\n\u003cli\u003eNeuroprotection following ischaemic events\u003c\/li\u003e\n\u003cli\u003eDopaminergic and serotonergic modulation\u003c\/li\u003e\n\u003cli\u003eNeuronal growth and synaptic plasticity\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eMechanism of action\u003c\/h3\u003e\u003cp\u003eActs on melanocortin receptors and markedly upregulates brain-derived neurotrophic factor, the protein governing neuron growth, maintenance and synaptic plasticity. It also modulates the enkephalin system and influences dopamine, serotonin and acetylcholine signalling.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e887.0 Da\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSequence\u003c\/td\u003e\n\u003ctd\u003eMet-Glu-His-Phe-Pro-Gly-Pro\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003e≥98% (HPLC)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eForm\u003c\/td\u003e\n\u003ctd\u003eLyophilised powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStorage\u003c\/td\u003e\n\u003ctd\u003e−20°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOrigin\u003c\/td\u003e\n\u003ctd\u003eUK\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\u003cdiv class=\"sn-note\"\u003e\n\u003cstrong\u003eResearch use only.\u003c\/strong\u003e Supplied strictly for in-vitro laboratory research. Not for human or animal consumption, and not for diagnostic or therapeutic use. To be handled only by qualified professionals. You must be 18 or over to purchase. Certificate of analysis available for every batch on request.\u003c\/div\u003e","brand":"Power Peptide UK","offers":[{"title":"10mg","offer_id":65659077820765,"sku":"PPUK-SEMAX-1","price":31.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1102\/9459\/7981\/files\/power-peptide-uk-vial.jpg?v=1787419069"},{"product_id":"selank","title":"Selank","description":"\u003cp\u003eTuftsin-derived heptapeptide studied for anxiolytic activity without sedation.\u003c\/p\u003e\u003ch3\u003eOverview\u003c\/h3\u003e\u003cp\u003eSelank is a synthetic analogue of the immunomodulatory peptide Tuftsin, developed by the Institute of Molecular Genetics in Russia. Research focuses on anxiolytic, nootropic and immunomodulatory properties in animal models.\u003c\/p\u003e\u003ch3\u003eResearch applications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eAnxiolytic activity without sedation in research models\u003c\/li\u003e\n\u003cli\u003eMemory and learning capacity\u003c\/li\u003e\n\u003cli\u003eEnkephalin metabolism stabilisation\u003c\/li\u003e\n\u003cli\u003eImmune modulation (IL-6)\u003c\/li\u003e\n\u003cli\u003eNo tolerance observed in research models\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eMechanism of action\u003c\/h3\u003e\u003cp\u003eModulates the GABAergic system and stabilises enkephalins, the endogenous opioid peptides regulating mood. Unlike benzodiazepines it does not downregulate GABA receptors in research models, which is the accepted explanation for the absence of tolerance.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e751.9 Da\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSequence\u003c\/td\u003e\n\u003ctd\u003eThr-Lys-Pro-Arg-Pro-Gly-Pro\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003e≥98% (HPLC)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eForm\u003c\/td\u003e\n\u003ctd\u003eLyophilised powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStorage\u003c\/td\u003e\n\u003ctd\u003e−20°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOrigin\u003c\/td\u003e\n\u003ctd\u003eUK\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\u003cdiv class=\"sn-note\"\u003e\n\u003cstrong\u003eResearch use only.\u003c\/strong\u003e Supplied strictly for in-vitro laboratory research. Not for human or animal consumption, and not for diagnostic or therapeutic use. To be handled only by qualified professionals. You must be 18 or over to purchase. Certificate of analysis available for every batch on request.\u003c\/div\u003e","brand":"Power Peptide UK","offers":[{"title":"10mg","offer_id":65659079098717,"sku":"PPUK-SELANK-1","price":31.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1102\/9459\/7981\/files\/power-peptide-uk-vial.jpg?v=1787419069"}],"url":"https:\/\/powerpeptidesuk.com\/collections\/cognitive.oembed","provider":"PowerPeps","version":"1.0","type":"link"}